Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 600082..600568 Replicon chromosome
Accession NC_017622
Organism Streptococcus suis A7

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag SSUA7_RS03000 Protein ID WP_011922754.1
Coordinates 600299..600568 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag SSUA7_RS02995 Protein ID WP_002938604.1
Coordinates 600082..600309 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUA7_RS02970 595124..595573 - 450 WP_009909619.1 MarR family transcriptional regulator -
SSUA7_RS10135 595867..596715 + 849 Protein_532 IS630 family transposase -
SSUA7_RS02980 596774..597271 + 498 WP_011922751.1 DUF5590 domain-containing protein -
SSUA7_RS02985 597268..598449 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
SSUA7_RS02990 598464..599810 + 1347 WP_011922752.1 asparagine--tRNA ligase -
SSUA7_RS02995 600082..600309 + 228 WP_002938604.1 hypothetical protein Antitoxin
SSUA7_RS03000 600299..600568 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUA7_RS03005 600974..602293 + 1320 WP_012775027.1 MATE family efflux transporter -
SSUA7_RS03010 602344..602721 + 378 WP_002937263.1 RidA family protein -
SSUA7_RS03015 602743..603630 + 888 WP_011922160.1 RNase adapter RapZ -
SSUA7_RS03020 603627..604601 + 975 WP_002937257.1 YvcK family protein -
SSUA7_RS03025 604598..605515 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T27137 WP_011922754.1 NC_017622:600299-600568 [Streptococcus suis A7]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T27137 NC_017622:600299-600568 [Streptococcus suis A7]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT27137 WP_002938604.1 NC_017622:600082-600309 [Streptococcus suis A7]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT27137 NC_017622:600082-600309 [Streptococcus suis A7]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References