Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 890596..891247 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name cptA Uniprot ID A0A8D9PM36
Locus tag PS052_RS04410 Protein ID WP_044714929.1
Coordinates 890843..891247 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS052_RS04405 Protein ID WP_000354046.1
Coordinates 890596..890862 (+) Length 89 a.a.

Genomic Context


PS052_RS04385PS052_RS04390PS052_RS04400PS052_RS04405PS052_RS04410PS052_RS04420PS052_RS04425PS052_RS04430PS052_RS04380PS052_RS04395PS052_RS04415
Location: 887786..888097 (312 bp)
Type: Others
Protein ID: WP_001182937.1
Location: 888265..888924 (660 bp)
Type: Others
Protein ID: WP_000250281.1
Location: 890376..890606 (231 bp)
Type: Others
Protein ID: WP_273765308.1
Location: 890596..890862 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 890843..891247 (405 bp)
Type: Toxin
Protein ID: WP_044714929.1
Location: 891919..892815 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 892840..893550 (711 bp)
Type: Others
Protein ID: WP_000748106.1
Location: 893556..895289 (1734 bp)
Type: Others
Protein ID: WP_000813238.1
Location: 886308..887741 (1434 bp)
Type: Others
Protein ID: WP_273765305.1
Location: 889364..890344 (981 bp)
Type: Others
Protein ID: WP_103053871.1
Location: 891286..891807 (522 bp)
Type: Others
Protein ID: WP_103053870.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PS052_RS04380 (886308)886308..887741-1434WP_273765305.16-phospho-beta-glucosidase BglA-
PS052_RS04385 (887786)887786..888097+312WP_001182937.1N(4)-acetylcytidine aminohydrolase-
PS052_RS04390 (888265)888265..888924+660WP_000250281.1hemolysin III family protein-
PS052_RS04395 (889364)889364..890344-981WP_103053871.1tRNA-modifying protein YgfZ-
PS052_RS04400 (890376)890376..890606+231WP_273765308.1hypothetical protein-
PS052_RS04405 (890596)890596..890862+267WP_000354046.1FAD assembly factor SdhEAntitoxin
PS052_RS04410 (890843)890843..891247+405WP_044714929.1protein YgfXToxin
PS052_RS04415 (891286)891286..891807-522WP_103053870.1flavodoxin FldB-
PS052_RS04420 (891919)891919..892815+897WP_000806638.1site-specific tyrosine recombinase XerD-
PS052_RS04425 (892840)892840..893550+711WP_000748106.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
PS052_RS04430 (893556)893556..895289+1734WP_000813238.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 10.2082

>T271366 WP_044714929.1 NZ_CP117558:890843-891247 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLCLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271366 WP_000354046.1 NZ_CP117558:890596-890862 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References