Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 890596..891247 Replicon chromosome
Accession NZ_CP117558
Organism Escherichia albertii strain BIA_8

Toxin (Protein)


Gene name cptA Uniprot ID A0A8D9PM36
Locus tag PS052_RS04410 Protein ID WP_044714929.1
Coordinates 890843..891247 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS052_RS04405 Protein ID WP_000354046.1
Coordinates 890596..890862 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS052_RS04380 (886308) 886308..887741 - 1434 WP_273765305.1 6-phospho-beta-glucosidase BglA -
PS052_RS04385 (887786) 887786..888097 + 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
PS052_RS04390 (888265) 888265..888924 + 660 WP_000250281.1 hemolysin III family protein -
PS052_RS04395 (889364) 889364..890344 - 981 WP_103053871.1 tRNA-modifying protein YgfZ -
PS052_RS04400 (890376) 890376..890606 + 231 WP_273765308.1 hypothetical protein -
PS052_RS04405 (890596) 890596..890862 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS052_RS04410 (890843) 890843..891247 + 405 WP_044714929.1 protein YgfX Toxin
PS052_RS04415 (891286) 891286..891807 - 522 WP_103053870.1 flavodoxin FldB -
PS052_RS04420 (891919) 891919..892815 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS052_RS04425 (892840) 892840..893550 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS052_RS04430 (893556) 893556..895289 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 10.2082

>T271366 WP_044714929.1 NZ_CP117558:890843-891247 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLCLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271366 WP_000354046.1 NZ_CP117558:890596-890862 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References