Detailed information of TA system TA027136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1989073..1989679
• Replicon: chromosome
• Accession: NC_017621
• Organism: Streptococcus suis D12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G7SEL6
• Locus tag: SSUD12_RS09795
• Protein ID: WP_014638724.1
• Coordinates: 1989073..1989402 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: G7SEL7
• Locus tag: SSUD12_RS09800
• Protein ID: WP_014638725.1
• Coordinates: 1989392..1989679 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUD12_RS09775	1984423..1986153	-	1731	WP_041179291.1	membrane protein	-
SSUD12_RS09780	1986356..1987228	-	873	WP_014638721.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
SSUD12_RS09785	1987406..1988575	-	1170	WP_014638722.1	hypothetical protein	-
SSUD12_RS09790	1988592..1988975	-	384	WP_014638723.1	DUF2513 domain-containing protein	-
SSUD12_RS09795	1989073..1989402	-	330	WP_014638724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSUD12_RS09800	1989392..1989679	-	288	WP_014638725.1	hypothetical protein	Antitoxin
SSUD12_RS09805	1989777..1990145	-	369	WP_014638726.1	hypothetical protein	-
SSUD12_RS09810	1990138..1990707	-	570	WP_041179234.1	ribonuclease M5	-
SSUD12_RS09815	1990691..1991473	-	783	WP_014638728.1	TatD family hydrolase	-
SSUD12_RS09820	1991580..1991717	-	138	WP_002939016.1	50S ribosomal protein L34	-
SSUD12_RS09825	1991885..1992880	-	996	WP_013730624.1	protein jag	-
SSUD12_RS09830	1992900..1993712	-	813	WP_004194552.1	YidC/Oxa1 family membrane protein insertase	-
SSUD12_RS09835	1993696..1994055	-	360	WP_004194560.1	ribonuclease P protein component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1983041..1984294	1253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-96)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12607.51 Da
• Isoelectric Point: 5.7640

>T27136 WP_014638724.1 NC_017621:c1989402-1989073 [Streptococcus suis D12]
MEFESYSVILAPAVEKELADIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Nucleotide

• Length: 330 bp

>T27136 NC_017621:c1989402-1989073 [Streptococcus suis D12]
ATGGAATTTGAGTCATATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGATATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCGGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTGACCCGAGGTTACGTTATTGGAAAAGAC
TACATTGCACTCTATCGTGTGGTCGAAAAAGAAGTGCGAGTTGGTCATCTCTTTGCGACTAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.4356

>AT27136 WP_014638725.1 NC_017621:c1989679-1989392 [Streptococcus suis D12]
MITIKKNAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GPGISLEIVKEKYGI

Nucleotide

• Length: 288 bp

>AT27136 NC_017621:c1989679-1989392 [Streptococcus suis D12]
TTGATAACTATAAAGAAGAATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGTTGGATTTGACTGCTGGTTTTAACCTCTTTTTACAAAACATTGCTGTAAAAAATGAGTTGCCCATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAACTTCAAAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGGCCAGGGATCAGCCTAGAAATCGTCAAAGAGAAGTATGGAATTTGA

Structures

Toxin

• AlphaFold DB: G7SEL6

Antitoxin

• AlphaFold DB: G7SEL7