Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2510880..2511481 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PS032_RS12525 Protein ID WP_137650472.1
Coordinates 2510880..2511263 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1ELZ9
Locus tag PS032_RS12530 Protein ID WP_001195490.1
Coordinates 2511260..2511481 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS12510 (2506286) 2506286..2507969 - 1684 Protein_2453 sulfatase -
PS032_RS12515 (2508340) 2508340..2509376 - 1037 Protein_2454 IS3 family transposase -
PS032_RS12520 (2509381) 2509381..2510938 + 1558 Protein_2455 autotransporter outer membrane beta-barrel domain-containing protein -
PS032_RS12525 (2510880) 2510880..2511263 - 384 WP_137650472.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS032_RS12530 (2511260) 2511260..2511481 - 222 WP_001195490.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS032_RS12535 (2511887) 2511887..2512282 + 396 WP_137650473.1 trans-aconitate 2-methyltransferase -
PS032_RS12540 (2512286) 2512286..2513200 - 915 WP_024164792.1 bestrophin family protein -
PS032_RS12545 (2513405) 2513405..2514856 - 1452 WP_105197997.1 tagaturonate reductase -
PS032_RS12550 (2515103) 2515103..2516390 - 1288 Protein_2461 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2508340..2509245 905
- inside Prophage - stx2B / stx2A 2508340..2605101 96761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14416.47 Da        Isoelectric Point: 9.5855

>T271346 WP_137650472.1 NZ_CP117556:c2511263-2510880 [Escherichia albertii]
MIWVSAQEVIAFHDRILQRFPGVAGLTDPGRAQALIYRVQNRVHYEGVTDLFELAATYWVAIARGHIFHDGNKRTAFFVT
MAFLWRNGIRIRDVDNSLENLTVEAATGEVSPLRRYAIRPDGGFLRG

Download         Length: 384 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8067.96 Da        Isoelectric Point: 4.6816

>AT271346 WP_001195490.1 NZ_CP117556:c2511481-2511260 [Escherichia albertii]
MQTYTSTQARANIATVLDTALNGEPVEITRRDGSSAVLISKAAFEAYQNAKLDAEFDAIMQRHEHTIEALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6PD20

References