Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1980913..1981538 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PS032_RS09730 Protein ID WP_000911314.1
Coordinates 1980913..1981311 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PS032_RS09735 Protein ID WP_273807068.1
Coordinates 1981311..1981538 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS09710 (1976377) 1976377..1976862 + 486 WP_000605865.1 hypothetical protein -
PS032_RS09715 (1976911) 1976911..1977642 + 732 WP_000782451.1 conjugal transfer complement resistance protein TraT -
PS032_RS09720 (1977846) 1977846..1978325 + 480 WP_001382783.1 hypothetical protein -
PS032_RS09725 (1978607) 1978607..1980904 + 2298 WP_273807067.1 type IV conjugative transfer system coupling protein TraD -
PS032_RS09730 (1980913) 1980913..1981311 - 399 WP_000911314.1 type II toxin-antitoxin system VapC family toxin Toxin
PS032_RS09735 (1981311) 1981311..1981538 - 228 WP_273807068.1 toxin-antitoxin system antitoxin VapB Antitoxin
PS032_RS09740 (1981620) 1981620..1982948 + 1329 Protein_1909 MobF family relaxase -
PS032_RS09745 (1983040) 1983040..1984212 + 1173 WP_053264206.1 IS21-like element IS21 family transposase -
PS032_RS09750 (1984212) 1984212..1985009 + 798 WP_123012753.1 IS21-like element IS21 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1977714..1991675 13961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14814.12 Da        Isoelectric Point: 7.8604

>T271339 WP_000911314.1 NZ_CP117556:c1981311-1980913 [Escherichia albertii]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELALQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8528.60 Da        Isoelectric Point: 4.5358

>AT271339 WP_273807068.1 NZ_CP117556:c1981538-1981311 [Escherichia albertii]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQLGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References