Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1365119..1365737 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS032_RS06770 Protein ID WP_001280991.1
Coordinates 1365119..1365337 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS032_RS06775 Protein ID WP_000344798.1
Coordinates 1365363..1365737 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS06735 (1360408) 1360408..1360980 + 573 WP_113622884.1 YbaY family lipoprotein -
PS032_RS06740 (1361010) 1361010..1361321 - 312 WP_000409915.1 MGMT family protein -
PS032_RS06750 (1361702) 1361702..1362055 + 354 WP_137649645.1 DUF1428 family protein -
PS032_RS06755 (1362093) 1362093..1363643 - 1551 WP_137649644.1 EAL domain-containing protein -
PS032_RS06760 (1363807) 1363807..1364277 - 471 WP_000136189.1 YlaC family protein -
PS032_RS06765 (1364385) 1364385..1364942 - 558 WP_000093562.1 maltose O-acetyltransferase -
PS032_RS06770 (1365119) 1365119..1365337 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS032_RS06775 (1365363) 1365363..1365737 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS032_RS06780 (1366292) 1366292..1369441 - 3150 WP_001132500.1 efflux RND transporter permease AcrB -
PS032_RS06785 (1369464) 1369464..1370657 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271337 WP_001280991.1 NZ_CP117556:c1365337-1365119 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT271337 WP_000344798.1 NZ_CP117556:c1365737-1365363 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References