Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1024394..1025045 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag PS032_RS05100 Protein ID WP_000244763.1
Coordinates 1024641..1025045 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PS032_RS05095 Protein ID WP_000354046.1
Coordinates 1024394..1024660 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS05065 (1019403) 1019403..1020296 + 894 WP_059214571.1 transporter -
PS032_RS05070 (1020344) 1020344..1021777 - 1434 WP_024164724.1 6-phospho-beta-glucosidase BglA -
PS032_RS05075 (1021822) 1021822..1022133 + 312 WP_137649989.1 N(4)-acetylcytidine aminohydrolase -
PS032_RS05080 (1022301) 1022301..1022960 + 660 WP_000250281.1 hemolysin III family protein -
PS032_RS05085 (1023162) 1023162..1024142 - 981 WP_137649988.1 tRNA-modifying protein YgfZ -
PS032_RS05090 (1024174) 1024174..1024404 + 231 WP_000181267.1 hypothetical protein -
PS032_RS05095 (1024394) 1024394..1024660 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PS032_RS05100 (1024641) 1024641..1025045 + 405 WP_000244763.1 protein YgfX Toxin
PS032_RS05105 (1025084) 1025084..1025605 - 522 WP_085456580.1 flavodoxin FldB -
PS032_RS05110 (1025717) 1025717..1026613 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PS032_RS05115 (1026638) 1026638..1027348 + 711 WP_000748105.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PS032_RS05120 (1027354) 1027354..1029087 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T271336 WP_000244763.1 NZ_CP117556:1024641-1025045 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271336 WP_000354046.1 NZ_CP117556:1024394-1024660 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References