Detailed information of TA system TA027133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 929472..929973
• Replicon: chromosome
• Accession: NC_017621
• Organism: Streptococcus suis D12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G7SDZ6
• Locus tag: SSUD12_RS04700
• Protein ID: WP_014637925.1
• Coordinates: 929707..929973 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G7SDZ5
• Locus tag: SSUD12_RS04695
• Protein ID: WP_014637924.1
• Coordinates: 929472..929723 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUD12_RS11685	925127..925264	+	138	WP_014637918.1	hypothetical protein	-
SSUD12_RS04670	925277..926009	+	733	Protein_866	beta-carotene 15,15'-monooxygenase	-
SSUD12_RS11690	926108..926248	+	141	WP_014637920.1	hypothetical protein	-
SSUD12_RS04680	926302..926649	+	348	WP_014637921.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
SSUD12_RS04685	926658..927410	+	753	WP_014637922.1	ABC transporter ATP-binding protein	-
SSUD12_RS04690	927411..929381	+	1971	WP_014637923.1	FtsX-like permease family protein	-
SSUD12_RS04695	929472..929723	+	252	WP_014637924.1	hypothetical protein	Antitoxin
SSUD12_RS04700	929707..929973	+	267	WP_014637925.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSUD12_RS04705	930012..930680	+	669	WP_024381849.1	response regulator transcription factor	-
SSUD12_RS04710	930677..931618	+	942	WP_014637927.1	sensor histidine kinase	-
SSUD12_RS04715	931695..933203	+	1509	Protein_875	phosphomannomutase/phosphoglucomutase	-
SSUD12_RS04720	933273..934343	-	1071	WP_014637928.1	tyrosine recombinase XerS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-87)

Antitoxin

• Protein of unknown function DUF6290 (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10345.99 Da
• Isoelectric Point: 10.7260

>T27133 WP_014637925.1 NC_017621:929707-929973 [Streptococcus suis D12]
MKTSYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Nucleotide

• Length: 267 bp

>T27133 NC_017621:929707-929973 [Streptococcus suis D12]
ATGAAGACCAGTTATAAACTCGTACCAACCGGTCGTTTTATCAAACAGTTGAAAAAGCTGGACAAATTTACTCAAAAGCA
GATTACCAACTACCTGTCTAGTCATGTGACCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGGTACCGTATCGGTAATTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9369.52 Da
• Isoelectric Point: 3.6675

>AT27133 WP_014637924.1 NC_017621:929472-929723 [Streptococcus suis D12]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAWAEYEADLANGIEPISWEEMLEDLGLTDE
DQL

Nucleotide

• Length: 252 bp

>AT27133 NC_017621:929472-929723 [Streptococcus suis D12]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTTTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAATACGATGCGCGCGTGGCAGACCTTGCTTGGGCAG
AATACGAGGCTGACTTGGCGAATGGAATTGAGCCGATAAGCTGGGAGGAAATGTTGGAAGATTTGGGGCTGACGGATGAA
GACCAGTTATAA

Structures

Toxin

• AlphaFold DB: G7SDZ6

Antitoxin

• AlphaFold DB: G7SDZ5