Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 725652..726318 Replicon chromosome
Accession NZ_CP117554
Organism Erwinia amylovora strain 99east-3-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag PTC76_RS03320 Protein ID WP_004161808.1
Coordinates 725899..726318 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag PTC76_RS03315 Protein ID WP_004155593.1
Coordinates 725652..725918 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC76_RS03295 (PTC76_03295) 722125..722854 + 730 Protein_647 SDR family oxidoreductase -
PTC76_RS03300 (PTC76_03300) 722959..723567 - 609 WP_004155587.1 HD domain-containing protein -
PTC76_RS03305 (PTC76_03305) 723780..724439 + 660 WP_004155588.1 hemolysin III family protein -
PTC76_RS03310 (PTC76_03310) 724440..725426 - 987 WP_004155590.1 tRNA-modifying protein YgfZ -
PTC76_RS03315 (PTC76_03315) 725652..725918 + 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
PTC76_RS03320 (PTC76_03320) 725899..726318 + 420 WP_004161808.1 protein YgfX Toxin
PTC76_RS03325 (PTC76_03325) 726436..726954 - 519 WP_004155596.1 flavodoxin FldB -
PTC76_RS03330 (PTC76_03330) 727184..728137 - 954 WP_004155597.1 DMT family transporter -
PTC76_RS03335 (PTC76_03335) 728647..730326 - 1680 WP_004155599.1 type III effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T271323 WP_004161808.1 NZ_CP117554:725899-726318 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT271323 WP_004155593.1 NZ_CP117554:725652-725918 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References