27132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 914109..915541 Replicon chromosome
Accession NC_017621
Organism Streptococcus suis D12

Toxin (Protein)


Gene name abiEi Uniprot ID G7SDX8
Locus tag SSUD12_RS04615 Protein ID WP_014637907.1
Coordinates 914109..914954 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID G7SDX9
Locus tag SSUD12_RS04620 Protein ID WP_014637908.1
Coordinates 914951..915541 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUD12_RS04595 910018..912111 + 2094 WP_004195696.1 type I DNA topoisomerase -
SSUD12_RS04600 912688..913182 + 495 WP_002936486.1 50S ribosomal protein L10 -
SSUD12_RS04605 913248..913613 + 366 WP_014637905.1 50S ribosomal protein L7/L12 -
SSUD12_RS04610 913804..914046 + 243 Protein_853 CHAP domain-containing protein -
SSUD12_RS04615 914109..914954 - 846 WP_014637907.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
SSUD12_RS04620 914951..915541 - 591 WP_014637908.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
SSUD12_RS04625 915823..916080 + 258 Protein_856 hypothetical protein -
SSUD12_RS04630 916385..916582 + 198 WP_014637910.1 helix-turn-helix transcriptional regulator -
SSUD12_RS04635 916595..918772 + 2178 WP_014637911.1 type I restriction-modification system subunit M -
SSUD12_RS11605 919191..919487 + 297 WP_079254973.1 HAD hydrolase-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32464.15 Da        Isoelectric Point: 5.4360

>T27132 WP_014637907.1 NC_017621:c914954-914109 [Streptococcus suis D12]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGITFVIQSITAIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IISYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Download         Length: 846 bp

>T27132 NC_017621:c914954-914109 [Streptococcus suis D12]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATCTTGAAAAAATTAAGTCAGAGCACCTATTCAAATCACTATATTTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATAACTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTGATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATATGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTTCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAAAAAGAAGACATTGACTTCATTCAGTTGAAAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAGGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23325.90 Da        Isoelectric Point: 7.3108

>AT27132 WP_014637908.1 NC_017621:c915541-914951 [Streptococcus suis D12]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHFVSKEYSELGITLVKTPMGNEVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Download         Length: 591 bp

>AT27132 NC_017621:c915541-914951 [Streptococcus suis D12]
ATGTCAAAAAAAGAGATTCTGCTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCACTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTTCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTATGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SDX8

Antitoxin

Source ID Structure
AlphaFold DB G7SDX9

References