Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4960288..4961546 Replicon chromosome
Accession NZ_CP117527
Organism Pseudomonas aeruginosa strain MF1

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PSP57_RS23240 Protein ID WP_003086331.1
Coordinates 4960288..4961043 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PSP57_RS23245 Protein ID WP_003086329.1
Coordinates 4961178..4961546 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSP57_RS23230 (PSP57_23230) 4955459..4958002 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
PSP57_RS23235 (PSP57_23235) 4958157..4959518 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PSP57_RS23240 (PSP57_23240) 4960288..4961043 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PSP57_RS23245 (PSP57_23245) 4961178..4961546 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PSP57_RS23250 (PSP57_23250) 4961619..4962905 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PSP57_RS23255 (PSP57_23255) 4962961..4964454 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
PSP57_RS23260 (PSP57_23260) 4964629..4965105 + 477 WP_004353334.1 elongation factor GreAB -
PSP57_RS23265 (PSP57_23265) 4965108..4965368 - 261 WP_023095977.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T271319 WP_003086331.1 NZ_CP117527:c4961043-4960288 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT271319 WP_003086329.1 NZ_CP117527:c4961546-4961178 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References