Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3915024..3916244 Replicon chromosome
Accession NZ_CP117527
Organism Pseudomonas aeruginosa strain MF1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PSP57_RS18150 Protein ID WP_003110488.1
Coordinates 3915666..3916244 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PSP57_RS18145 Protein ID WP_003088112.1
Coordinates 3915024..3915578 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSP57_RS18120 (PSP57_18120) 3910592..3911143 + 552 WP_003132721.1 XRE family transcriptional regulator -
PSP57_RS18125 (PSP57_18125) 3911140..3911538 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PSP57_RS18130 (PSP57_18130) 3911551..3911874 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PSP57_RS18135 (PSP57_18135) 3912205..3912666 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PSP57_RS18140 (PSP57_18140) 3912671..3914866 + 2196 WP_023095788.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PSP57_RS18145 (PSP57_18145) 3915024..3915578 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PSP57_RS18150 (PSP57_18150) 3915666..3916244 + 579 WP_003110488.1 HD domain-containing protein Toxin
PSP57_RS18155 (PSP57_18155) 3916354..3917541 - 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
PSP57_RS18160 (PSP57_18160) 3917531..3919702 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
PSP57_RS18165 (PSP57_18165) 3919692..3920969 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T271318 WP_003110488.1 NZ_CP117527:3915666-3916244 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT271318 WP_003088112.1 NZ_CP117527:3915024-3915578 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References