Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143396..143901 Replicon chromosome
Accession NZ_CP117527
Organism Pseudomonas aeruginosa strain MF1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PSP57_RS00665 Protein ID WP_003083773.1
Coordinates 143396..143677 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PSP57_RS00670 Protein ID WP_003083775.1
Coordinates 143674..143901 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSP57_RS00640 (PSP57_00640) 138647..139996 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PSP57_RS00645 (PSP57_00645) 140045..140731 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PSP57_RS00650 (PSP57_00650) 140832..141566 + 735 WP_003083764.1 GntR family transcriptional regulator -
PSP57_RS00655 (PSP57_00655) 141746..142156 + 411 WP_003110659.1 aegerolysin family protein -
PSP57_RS00660 (PSP57_00660) 142188..143096 - 909 WP_003083769.1 LysR family transcriptional regulator -
PSP57_RS00665 (PSP57_00665) 143396..143677 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PSP57_RS00670 (PSP57_00670) 143674..143901 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PSP57_RS00675 (PSP57_00675) 144077..144697 - 621 WP_003101226.1 hypothetical protein -
PSP57_RS00680 (PSP57_00680) 144798..145298 + 501 WP_003083778.1 LEA type 2 family protein -
PSP57_RS00685 (PSP57_00685) 145371..145712 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
PSP57_RS00690 (PSP57_00690) 145796..147223 - 1428 WP_003083784.1 GABA permease -
PSP57_RS00695 (PSP57_00695) 147392..148885 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T271315 WP_003083773.1 NZ_CP117527:c143677-143396 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT271315 WP_003083775.1 NZ_CP117527:c143901-143674 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References