27130

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 565538..566207 Replicon chromosome
Accession NC_017621
Organism Streptococcus suis D12

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag SSUD12_RS02950 Protein ID WP_014637653.1
Coordinates 565538..565720 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G7SGM2
Locus tag SSUD12_RS02955 Protein ID WP_014637654.1
Coordinates 565758..566207 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUD12_RS02925 560875..562203 - 1329 WP_014637648.1 PH domain-containing protein -
SSUD12_RS02930 562203..562640 - 438 WP_041179201.1 hypothetical protein -
SSUD12_RS11600 562744..562896 - 153 WP_014637649.1 aureocin A53 family class IId bacteriocin -
SSUD12_RS02935 563101..563784 + 684 WP_014637650.1 hypothetical protein -
SSUD12_RS02940 563786..564643 + 858 WP_014637651.1 ABC transporter ATP-binding protein -
SSUD12_RS02950 565538..565720 + 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
SSUD12_RS02955 565758..566207 + 450 WP_014637654.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SSUD12_RS02960 566368..567411 - 1044 WP_029171529.1 Zn-dependent alcohol dehydrogenase -
SSUD12_RS02965 567565..568425 + 861 WP_014637656.1 SAM-dependent methyltransferase TehB -
SSUD12_RS02970 568618..570510 + 1893 WP_014637657.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T27130 WP_014637653.1 NC_017621:565538-565720 [Streptococcus suis D12]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T27130 NC_017621:565538-565720 [Streptococcus suis D12]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16664.69 Da        Isoelectric Point: 3.9458

>AT27130 WP_014637654.1 NC_017621:565758-566207 [Streptococcus suis D12]
MLVTYPALFYFDDTDGANAPYFVTFPDFEYSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp

>AT27130 NC_017621:565758-566207 [Streptococcus suis D12]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGTATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGTATGAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure
AlphaFold DB G7SGM2

References