271293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2691944..2692515 Replicon chromosome
Accession NZ_CP117511
Organism Enterococcus faecalis strain CQNBZ21-135

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PSC79_RS12935 Protein ID WP_002354774.1
Coordinates 2691944..2692285 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PSC79_RS12940 Protein ID WP_002354773.1
Coordinates 2692285..2692515 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC79_RS12930 (2687959) 2687959..2691573 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PSC79_RS12935 (2691944) 2691944..2692285 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PSC79_RS12940 (2692285) 2692285..2692515 - 231 WP_002354773.1 hypothetical protein Antitoxin
PSC79_RS12945 (2692846) 2692846..2693061 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PSC79_RS12950 (2693200) 2693200..2694192 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
PSC79_RS12955 (2694456) 2694456..2695094 - 639 WP_073438309.1 lytic polysaccharide monooxygenase -
PSC79_RS12960 (2695780) 2695780..2697396 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T271293 WP_002354774.1 NZ_CP117511:c2692285-2691944 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT271293 WP_002354773.1 NZ_CP117511:c2692515-2692285 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References