271288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 395687..396239 Replicon chromosome
Accession NZ_CP117511
Organism Enterococcus faecalis strain CQNBZ21-135

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag PSC79_RS02020 Protein ID WP_002355414.1
Coordinates 395931..396239 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID -
Locus tag PSC79_RS02015 Protein ID WP_034439854.1
Coordinates 395687..395929 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC79_RS02005 (394500) 394500..395354 + 855 WP_002364921.1 ParA family protein -
PSC79_RS02010 (395425) 395425..395640 + 216 WP_002355411.1 peptide-binding protein -
PSC79_RS02015 (395687) 395687..395929 + 243 WP_034439854.1 antitoxin Antitoxin
PSC79_RS02020 (395931) 395931..396239 + 309 WP_002355414.1 zeta toxin family protein Toxin
PSC79_RS02025 (396319) 396319..396741 - 423 WP_229236149.1 tyrosine-type recombinase/integrase -
PSC79_RS02030 (396792) 396792..397292 - 501 WP_002355415.1 HAD family hydrolase -
PSC79_RS02035 (397297) 397297..398064 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
PSC79_RS02040 (398544) 398544..398969 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
PSC79_RS02045 (398986) 398986..399501 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
PSC79_RS02050 (399512) 399512..400444 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 379806..397292 17486
- inside Prophage - - 379806..396239 16433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(1-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T271288 WP_002355414.1 NZ_CP117511:395931-396239 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9519.79 Da        Isoelectric Point: 4.5615

>AT271288 WP_034439854.1 NZ_CP117511:395687-395929 [Enterococcus faecalis]
IEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILTKEKVA

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure

References