Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 19452..20589 Replicon plasmid pJXZ077-29K
Accession NZ_CP117509
Organism Enterococcus faecalis strain CQJXZ21-077

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag PSC78_RS14370 Protein ID WP_024417198.1
Coordinates 19726..20589 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag PSC78_RS14365 Protein ID WP_000301765.1
Coordinates 19452..19724 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC78_RS14340 (PSC78_14340) 15177..15347 + 171 WP_000713595.1 hypothetical protein -
PSC78_RS14345 (PSC78_14345) 15361..15978 + 618 WP_159162395.1 recombinase family protein -
PSC78_RS14350 (PSC78_14350) 15978..18122 + 2145 WP_273961519.1 type IA DNA topoisomerase -
PSC78_RS14355 (PSC78_14355) 18225..19121 + 897 WP_002387620.1 ParA family protein -
PSC78_RS14360 (PSC78_14360) 19220..19435 + 216 WP_273961499.1 peptide-binding protein -
PSC78_RS14365 (PSC78_14365) 19452..19724 + 273 WP_000301765.1 antitoxin Antitoxin
PSC78_RS14370 (PSC78_14370) 19726..20589 + 864 WP_024417198.1 zeta toxin family protein Toxin
PSC78_RS14375 (PSC78_14375) 21030..21347 + 318 WP_002338433.1 hypothetical protein -
PSC78_RS14380 (PSC78_14380) 21881..22378 + 498 WP_010713926.1 molecular chaperone DnaJ -
PSC78_RS14385 (PSC78_14385) 22567..23739 + 1173 WP_032495458.1 IS256-like element ISEnfa4 family transposase -
PSC78_RS14390 (PSC78_14390) 24172..25221 - 1050 WP_273961520.1 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid cfr / aac(6')-aph(2'') - 1..29927 29927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32404.02 Da        Isoelectric Point: 6.9964

>T271285 WP_024417198.1 NZ_CP117509:19726-20589 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLEKELNRKVSGKEIQ
PTLERIEQKMVLNKHQETPEFKAIQQKLESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT271285 WP_000301765.1 NZ_CP117509:19452-19724 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References