27128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1501285..1501768 Replicon chromosome
Accession NC_017620
Organism Streptococcus suis D9

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag SSUD9_RS07310 Protein ID WP_009910443.1
Coordinates 1501285..1501545 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSUD9_RS07315 Protein ID WP_012775256.1
Coordinates 1501547..1501768 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUD9_RS07285 1496670..1497899 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
SSUD9_RS07290 1497889..1499055 - 1167 WP_002935690.1 AI-2E family transporter -
SSUD9_RS07295 1499191..1500195 + 1005 WP_009910438.1 lactonase family protein -
SSUD9_RS07300 1500259..1500444 + 186 WP_002935693.1 hypothetical protein -
SSUD9_RS07305 1500477..1501118 - 642 WP_014637073.1 HAD family hydrolase -
SSUD9_RS07310 1501285..1501545 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUD9_RS07315 1501547..1501768 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSUD9_RS07320 1502078..1503385 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSUD9_RS07325 1503535..1503987 + 453 WP_013730449.1 DUF1694 domain-containing protein -
SSUD9_RS07330 1503997..1504224 - 228 WP_002935708.1 hypothetical protein -
SSUD9_RS07335 1504215..1505342 - 1128 WP_002935718.1 glycerate kinase -
SSUD9_RS07340 1505450..1506100 + 651 WP_002935722.1 HAD family hydrolase -
SSUD9_RS07345 1506131..1506766 - 636 WP_002935723.1 phosphoserine phosphatase SerB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T27128 WP_009910443.1 NC_017620:c1501545-1501285 [Streptococcus suis D9]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T27128 NC_017620:c1501545-1501285 [Streptococcus suis D9]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT27128 WP_012775256.1 NC_017620:c1501768-1501547 [Streptococcus suis D9]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT27128 NC_017620:c1501768-1501547 [Streptococcus suis D9]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References