Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2791852..2792423 Replicon chromosome
Accession NZ_CP117508
Organism Enterococcus faecalis strain CQJXZ21-077

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PSC78_RS13650 Protein ID WP_002354774.1
Coordinates 2791852..2792193 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PSC78_RS13655 Protein ID WP_002354773.1
Coordinates 2792193..2792423 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC78_RS13645 (2787867) 2787867..2791481 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PSC78_RS13650 (2791852) 2791852..2792193 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PSC78_RS13655 (2792193) 2792193..2792423 - 231 WP_002354773.1 hypothetical protein Antitoxin
PSC78_RS13660 (2792598) 2792598..2792813 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PSC78_RS13665 (2792952) 2792952..2793944 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
PSC78_RS13670 (2794208) 2794208..2794804 - 597 WP_002414968.1 lytic polysaccharide monooxygenase -
PSC78_RS13675 (2795530) 2795530..2797146 + 1617 WP_104681241.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T271276 WP_002354774.1 NZ_CP117508:c2792193-2791852 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT271276 WP_002354773.1 NZ_CP117508:c2792423-2792193 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References