271265

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 6486..7623 Replicon plasmid pJXZ076-poxtA-19K
Accession NZ_CP117507
Organism Enterococcus faecalis strain CQJXZ21-076

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag PSC77_RS14855 Protein ID WP_100185210.1
Coordinates 6486..7349 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag PSC77_RS14860 Protein ID WP_000301765.1
Coordinates 7351..7623 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC77_RS14820 (PSC77_14820) 1663..2325 - 663 WP_001092058.1 class I SAM-dependent methyltransferase -
PSC77_RS14825 (PSC77_14825) 2716..3447 + 732 WP_002360844.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
PSC77_RS14830 (PSC77_14830) 3572..4354 - 783 WP_216468638.1 aminoglycoside nucleotidyltransferase ANT(9) -
PSC77_RS14835 (PSC77_14835) 4505..4711 - 207 Protein_5 acyltransferase -
PSC77_RS14840 (PSC77_14840) 4785..5465 + 681 WP_013646119.1 IS6-like element IS1216 family transposase -
PSC77_RS14845 (PSC77_14845) 5521..5709 - 189 Protein_7 DnaJ domain-containing protein -
PSC77_RS14850 (PSC77_14850) 5729..6046 - 318 WP_002338433.1 hypothetical protein -
PSC77_RS14855 (PSC77_14855) 6486..7349 - 864 WP_100185210.1 zeta toxin family protein Toxin
PSC77_RS14860 (PSC77_14860) 7351..7623 - 273 WP_000301765.1 antitoxin Antitoxin
PSC77_RS14865 (PSC77_14865) 7640..7855 - 216 WP_002295735.1 peptide-binding protein -
PSC77_RS14870 (PSC77_14870) 7954..8850 - 897 WP_002304405.1 ParA family protein -
PSC77_RS14875 (PSC77_14875) 8925..11069 - 2145 WP_225001404.1 type IA DNA topoisomerase -
PSC77_RS14880 (PSC77_14880) 11069..11686 - 618 WP_002295591.1 recombinase family protein -
PSC77_RS14885 (PSC77_14885) 11700..11870 - 171 WP_000713595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(A) / ant(9)-Ia / Cfr(D) / poxtA - 1..19987 19987
- flank IS/Tn erm(A) / ant(9)-Ia - 2716..5465 2749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32416.95 Da        Isoelectric Point: 6.6610

>T271265 WP_100185210.1 NZ_CP117507:c7349-6486 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT271265 WP_000301765.1 NZ_CP117507:c7623-7351 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References