Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 54403..55022 Replicon plasmid pJXZ076-99K
Accession NZ_CP117504
Organism Enterococcus faecalis strain CQJXZ21-076

Toxin (Protein)


Gene name mazF Uniprot ID R3H4V2
Locus tag PSC77_RS13910 Protein ID WP_000241511.1
Coordinates 54403..54765 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3H5D1
Locus tag PSC77_RS13915 Protein ID WP_000245205.1
Coordinates 54759..55022 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC77_RS13895 (PSC77_13895) 49813..51744 - 1932 WP_010816308.1 sucrose-specific PTS transporter subunit IIBC -
PSC77_RS13900 (PSC77_13900) 51935..53374 + 1440 WP_002367771.1 sucrose-6-phosphate hydrolase -
PSC77_RS13905 (PSC77_13905) 53376..54338 + 963 WP_002367770.1 LacI family DNA-binding transcriptional regulator -
PSC77_RS13910 (PSC77_13910) 54403..54765 - 363 WP_000241511.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PSC77_RS13915 (PSC77_13915) 54759..55022 - 264 WP_000245205.1 PbsX family transcriptional regulator Antitoxin
PSC77_RS13920 (PSC77_13920) 55199..55819 + 621 WP_048941608.1 recombinase family protein -
PSC77_RS13925 (PSC77_13925) 55836..56044 + 209 Protein_68 hypothetical protein -
PSC77_RS13930 (PSC77_13930) 56041..56967 + 927 WP_010706945.1 AbiH family protein -
PSC77_RS13935 (PSC77_13935) 56985..57806 + 822 WP_048941604.1 DUF5677 domain-containing protein -
PSC77_RS13940 (PSC77_13940) 58049..58177 - 129 WP_002409262.1 hypothetical protein -
PSC77_RS13945 (PSC77_13945) 58270..58521 + 252 WP_002399487.1 hypothetical protein -
PSC77_RS13950 (PSC77_13950) 58637..59953 + 1317 WP_010815752.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 1..99966 99966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13585.78 Da        Isoelectric Point: 9.6107

>T271262 WP_000241511.1 NZ_CP117504:c54765-54403 [Enterococcus faecalis]
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF

Download         Length: 363 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10059.46 Da        Isoelectric Point: 5.1585

>AT271262 WP_000245205.1 NZ_CP117504:c55022-54759 [Enterococcus faecalis]
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3H4V2

Antitoxin

Source ID Structure
AlphaFold DB R3H5D1

References