27126

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1022208..1022694 Replicon chromosome
Accession NC_017620
Organism Streptococcus suis D9

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag SSUD9_RS05000 Protein ID WP_002935012.1
Coordinates 1022208..1022465 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag SSUD9_RS05005 Protein ID WP_002935014.1
Coordinates 1022455..1022694 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUD9_RS04980 1017840..1018910 + 1071 WP_014636926.1 tyrosine recombinase XerS -
SSUD9_RS04985 1018980..1020490 - 1511 Protein_931 phosphomannomutase/phosphoglucomutase -
SSUD9_RS04990 1020566..1021507 - 942 WP_002935009.1 sensor histidine kinase -
SSUD9_RS04995 1021504..1022169 - 666 WP_009909826.1 response regulator transcription factor -
SSUD9_RS05000 1022208..1022465 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSUD9_RS05005 1022455..1022694 - 240 WP_002935014.1 hypothetical protein Antitoxin
SSUD9_RS05010 1022786..1024756 - 1971 WP_013730363.1 FtsX-like permease family protein -
SSUD9_RS05015 1024757..1025509 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
SSUD9_RS05020 1025526..1025909 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
SSUD9_RS11475 1025922..1026062 - 141 WP_002935023.1 hypothetical protein -
SSUD9_RS05030 1026201..1027367 - 1167 WP_014636928.1 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T27126 WP_002935012.1 NC_017620:c1022465-1022208 [Streptococcus suis D9]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T27126 NC_017620:c1022465-1022208 [Streptococcus suis D9]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT27126 WP_002935014.1 NC_017620:c1022694-1022455 [Streptococcus suis D9]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT27126 NC_017620:c1022694-1022455 [Streptococcus suis D9]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References