271257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2730450..2731021 Replicon chromosome
Accession NZ_CP117503
Organism Enterococcus faecalis strain CQJXZ21-076

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PSC77_RS13125 Protein ID WP_002354774.1
Coordinates 2730450..2730791 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag PSC77_RS13130 Protein ID WP_002367500.1
Coordinates 2730791..2731021 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC77_RS13120 (2726465) 2726465..2730079 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PSC77_RS13125 (2730450) 2730450..2730791 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PSC77_RS13130 (2730791) 2730791..2731021 - 231 WP_002367500.1 hypothetical protein Antitoxin
PSC77_RS13135 (2731344) 2731344..2731559 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PSC77_RS13140 (2731698) 2731698..2732690 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
PSC77_RS13145 (2732757) 2732757..2733389 - 633 WP_002358972.1 RloB family protein -
PSC77_RS13150 (2733398) 2733398..2734693 - 1296 WP_002410675.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T271257 WP_002354774.1 NZ_CP117503:c2730791-2730450 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT271257 WP_002367500.1 NZ_CP117503:c2731021-2730791 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References