Detailed information of TA system TA027125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 776689..777175
• Replicon: chromosome
• Accession: NC_017620
• Organism: Streptococcus suis D9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SSUD9_RS03860
• Protein ID: WP_014636891.1
• Coordinates: 776906..777175 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5AGV1
• Locus tag: SSUD9_RS03855
• Protein ID: WP_002938604.1
• Coordinates: 776689..776916 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUD9_RS03830	771954..772499	-	546	WP_002938614.1	NAD(P)H-dependent oxidoreductase	-
SSUD9_RS03835	772562..773011	-	450	WP_002938613.1	MarR family transcriptional regulator	-
SSUD9_RS03840	773314..773811	+	498	WP_002938611.1	DUF5590 domain-containing protein	-
SSUD9_RS03845	773808..774989	+	1182	WP_002938610.1	pyridoxal phosphate-dependent aminotransferase	-
SSUD9_RS03850	775004..776350	+	1347	WP_014636890.1	asparagine--tRNA ligase	-
SSUD9_RS03855	776689..776916	+	228	WP_002938604.1	hypothetical protein	Antitoxin
SSUD9_RS03860	776906..777175	+	270	WP_014636891.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSUD9_RS03865	777671..779005	+	1335	WP_014636892.1	MATE family efflux transporter	-
SSUD9_RS03870	779071..780360	+	1290	WP_014636745.1	IS4-like element ISSsu2 family transposase	-
SSUD9_RS03875	780692..781069	+	378	WP_002937263.1	RidA family protein	-
SSUD9_RS03880	781091..781978	+	888	WP_002937261.1	RNase adapter RapZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	779071..780360	1289

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10465.55 Da
• Isoelectric Point: 10.5016

>T27125 WP_014636891.1 NC_017620:776906-777175 [Streptococcus suis D9]
MAYKLVLSDDALKRLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Nucleotide

• Length: 270 bp

>T27125 NC_017620:776906-777175 [Streptococcus suis D9]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCGGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8450.51 Da
• Isoelectric Point: 4.1589

>AT27125 WP_002938604.1 NC_017620:776689-776916 [Streptococcus suis D9]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Nucleotide

• Length: 228 bp

>AT27125 NC_017620:776689-776916 [Streptococcus suis D9]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A140EXF0