Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 141054..141964 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP117482 | ||
| Organism | Klebsiella pneumoniae strain DS-1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | PPH92_RS26410 | Protein ID | WP_004181896.1 |
| Coordinates | 141494..141964 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | PPH92_RS26405 | Protein ID | WP_004181895.1 |
| Coordinates | 141054..141497 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PPH92_RS26385 (PPH92_26385) | 138119..138334 | - | 216 | Protein_141 | IS200/IS605 family transposase | - |
| PPH92_RS26390 (PPH92_26390) | 138336..138905 | + | 570 | Protein_142 | transposase | - |
| PPH92_RS26395 (PPH92_26395) | 139260..139682 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| PPH92_RS26400 (PPH92_26400) | 139682..140953 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| PPH92_RS26405 (PPH92_26405) | 141054..141497 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| PPH92_RS26410 (PPH92_26410) | 141494..141964 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| PPH92_RS26415 (PPH92_26415) | 142074..142334 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| PPH92_RS26420 (PPH92_26420) | 142905..144086 | - | 1182 | WP_004883380.1 | IS481 family transposase | - |
| PPH92_RS26425 (PPH92_26425) | 144158..144316 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| PPH92_RS26430 (PPH92_26430) | 144919..145893 | + | 975 | WP_014386572.1 | hypothetical protein | - |
| PPH92_RS26435 (PPH92_26435) | 146091..146468 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..205106 | 205106 | |
| - | inside | IScluster/Tn | - | - | 138552..144086 | 5534 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T271242 WP_004181896.1 NZ_CP117482:141494-141964 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT271242 WP_004181895.1 NZ_CP117482:141054-141497 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |