Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5198288..5198913 Replicon chromosome
Accession NZ_CP117481
Organism Klebsiella pneumoniae strain DS-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PPH92_RS25315 Protein ID WP_111459801.1
Coordinates 5198288..5198671 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag PPH92_RS25320 Protein ID WP_004150355.1
Coordinates 5198671..5198913 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPH92_RS25300 (5195654) 5195654..5196556 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
PPH92_RS25305 (5196553) 5196553..5197188 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
PPH92_RS25310 (5197185) 5197185..5198114 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
PPH92_RS25315 (5198288) 5198288..5198671 - 384 WP_111459801.1 type II toxin-antitoxin system VapC family toxin Toxin
PPH92_RS25320 (5198671) 5198671..5198913 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
PPH92_RS25325 (5199118) 5199118..5200035 + 918 WP_004187175.1 alpha/beta hydrolase -
PPH92_RS25330 (5200049) 5200049..5200990 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
PPH92_RS25335 (5201035) 5201035..5201472 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
PPH92_RS25340 (5201469) 5201469..5202329 - 861 WP_004146232.1 virulence factor BrkB family protein -
PPH92_RS25345 (5202323) 5202323..5202922 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14359.58 Da        Isoelectric Point: 7.3178

>T271241 WP_111459801.1 NZ_CP117481:c5198671-5198288 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWLEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT271241 WP_004150355.1 NZ_CP117481:c5198913-5198671 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References