Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4703594..4704110 Replicon chromosome
Accession NZ_CP117481
Organism Klebsiella pneumoniae strain DS-1

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag PPH92_RS22965 Protein ID WP_009309309.1
Coordinates 4703594..4703878 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PPH92_RS22970 Protein ID WP_002886901.1
Coordinates 4703868..4704110 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPH92_RS22940 (4699070) 4699070..4699333 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
PPH92_RS22945 (4699463) 4699463..4699636 + 174 WP_178941634.1 hypothetical protein -
PPH92_RS22950 (4699639) 4699639..4700382 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PPH92_RS22955 (4700739) 4700739..4702877 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PPH92_RS22960 (4703126) 4703126..4703590 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PPH92_RS22965 (4703594) 4703594..4703878 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PPH92_RS22970 (4703868) 4703868..4704110 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PPH92_RS22975 (4704188) 4704188..4706098 - 1911 WP_009486549.1 PRD domain-containing protein -
PPH92_RS22980 (4706121) 4706121..4707275 - 1155 WP_004178372.1 lactonase family protein -
PPH92_RS22985 (4707342) 4707342..4708082 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T271239 WP_009309309.1 NZ_CP117481:c4703878-4703594 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT271239 WP_002886901.1 NZ_CP117481:c4704110-4703868 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References