Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4589347..4590157 Replicon chromosome
Accession NZ_CP117481
Organism Klebsiella pneumoniae strain DS-1

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag PPH92_RS22475 Protein ID WP_156731902.1
Coordinates 4589347..4589880 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag PPH92_RS22480 Protein ID WP_002887278.1
Coordinates 4589891..4590157 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPH92_RS22470 (4588178) 4588178..4589299 + 1122 WP_156731901.1 cupin domain-containing protein -
PPH92_RS22475 (4589347) 4589347..4589880 - 534 WP_156731902.1 type II toxin-antitoxin system toxin KacT Toxin
PPH92_RS22480 (4589891) 4589891..4590157 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
PPH92_RS22485 (4590260) 4590260..4591693 - 1434 WP_156731903.1 Cu(+)/Ag(+) sensor histidine kinase -
PPH92_RS22490 (4591683) 4591683..4592366 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
PPH92_RS22495 (4592538) 4592538..4593923 + 1386 WP_009484676.1 efflux transporter outer membrane subunit -
PPH92_RS22500 (4593941) 4593941..4594285 + 345 WP_065889379.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19895.76 Da        Isoelectric Point: 5.7068

>T271238 WP_156731902.1 NZ_CP117481:c4589880-4589347 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSRDSVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT271238 WP_002887278.1 NZ_CP117481:c4590157-4589891 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References