Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2675190..2676778 Replicon chromosome
Accession NZ_CP117481
Organism Klebsiella pneumoniae strain DS-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag PPH92_RS13240 Protein ID WP_016946382.1
Coordinates 2675190..2676512 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PPH92_RS13245 Protein ID WP_024622638.1
Coordinates 2676512..2676778 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPH92_RS13225 (2670246) 2670246..2672747 + 2502 WP_038807929.1 fimbria/pilus outer membrane usher protein -
PPH92_RS13230 (2672735) 2672735..2673739 + 1005 WP_156731549.1 fimbrial protein -
PPH92_RS13235 (2673881) 2673881..2675173 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PPH92_RS13240 (2675190) 2675190..2676512 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
PPH92_RS13245 (2676512) 2676512..2676778 - 267 WP_024622638.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PPH92_RS13250 (2677043) 2677043..2677369 - 327 WP_004184023.1 hydroxyisourate hydrolase -
PPH92_RS13255 (2677366) 2677366..2677866 - 501 WP_094310433.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PPH92_RS13260 (2677844) 2677844..2679223 - 1380 WP_156731548.1 nucleobase:cation symporter-2 family protein -
PPH92_RS13265 (2679569) 2679569..2680723 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PPH92_RS13270 (2680704) 2680704..2681627 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T271236 WP_016946382.1 NZ_CP117481:c2676512-2675190 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9924.30 Da        Isoelectric Point: 8.5912

>AT271236 WP_024622638.1 NZ_CP117481:c2676778-2676512 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYMKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure

References