Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839298..839955 Replicon chromosome
Accession NZ_CP117481
Organism Klebsiella pneumoniae strain DS-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag PPH92_RS04165 Protein ID WP_002916310.1
Coordinates 839545..839955 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PPH92_RS04160 Protein ID WP_002916312.1
Coordinates 839298..839564 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPH92_RS04135 (834454) 834454..835887 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
PPH92_RS04140 (836006) 836006..836734 - 729 WP_273857011.1 MurR/RpiR family transcriptional regulator -
PPH92_RS04145 (836784) 836784..837095 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PPH92_RS04150 (837259) 837259..837918 + 660 WP_002916317.1 hemolysin III family protein -
PPH92_RS04155 (838069) 838069..839052 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
PPH92_RS04160 (839298) 839298..839564 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PPH92_RS04165 (839545) 839545..839955 + 411 WP_002916310.1 protein YgfX Toxin
PPH92_RS04170 (839962) 839962..840483 - 522 WP_002916308.1 flavodoxin FldB -
PPH92_RS04175 (840584) 840584..841480 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PPH92_RS04180 (841503) 841503..842216 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PPH92_RS04185 (842222) 842222..843955 + 1734 WP_108452515.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T271231 WP_002916310.1 NZ_CP117481:839545-839955 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT271231 WP_002916312.1 NZ_CP117481:839298-839564 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References