Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 753089..753864 Replicon chromosome
Accession NZ_CP117481
Organism Klebsiella pneumoniae strain DS-1

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag PPH92_RS03745 Protein ID WP_004889762.1
Coordinates 753379..753864 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag PPH92_RS03740 Protein ID WP_004150912.1
Coordinates 753089..753382 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPH92_RS03720 (748297) 748297..748899 - 603 WP_156731696.1 short chain dehydrogenase -
PPH92_RS03725 (748997) 748997..749908 + 912 WP_156731695.1 LysR family transcriptional regulator -
PPH92_RS03730 (749909) 749909..751057 - 1149 WP_020316731.1 PLP-dependent aspartate aminotransferase family protein -
PPH92_RS03735 (751068) 751068..752444 - 1377 WP_178941560.1 cystathionine beta-synthase -
PPH92_RS03740 (753089) 753089..753382 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
PPH92_RS03745 (753379) 753379..753864 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
PPH92_RS03750 (754043) 754043..754495 - 453 WP_080816334.1 hypothetical protein -
PPH92_RS03755 (754610) 754610..754829 - 220 Protein_739 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T271230 WP_004889762.1 NZ_CP117481:753379-753864 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT271230 WP_004150912.1 NZ_CP117481:753089-753382 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References