Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 17456..18153 Replicon plasmid unnamed2
Accession NZ_CP117473
Organism Sphingobium sp. YC-XJ3

Toxin (Protein)


Gene name tad Uniprot ID T0J3S2
Locus tag PO876_RS26585 Protein ID WP_013041565.1
Coordinates 17456..17830 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID T0G937
Locus tag PO876_RS26590 Protein ID WP_006964370.1
Coordinates 17827..18153 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO876_RS26565 (PO876_26565) 12590..13798 + 1209 WP_011607937.1 3-oxoadipyl-CoA thiolase -
PO876_RS26570 (PO876_26570) 14037..14801 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
PO876_RS26575 (PO876_26575) 14941..16761 + 1821 Protein_16 Tn3 family transposase -
PO876_RS26580 (PO876_26580) 16780..17034 - 255 WP_013041563.1 hypothetical protein -
PO876_RS26585 (PO876_26585) 17456..17830 + 375 WP_013041565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PO876_RS26590 (PO876_26590) 17827..18153 + 327 WP_006964370.1 helix-turn-helix transcriptional regulator Antitoxin
PO876_RS26595 (PO876_26595) 18153..18395 + 243 WP_013041566.1 hypothetical protein -
PO876_RS26600 (PO876_26600) 18611..19396 - 786 WP_004213209.1 SDR family NAD(P)-dependent oxidoreductase -
PO876_RS26605 (PO876_26605) 19393..19944 - 552 WP_004213210.1 recombinase family protein -
PO876_RS26610 (PO876_26610) 20084..23041 + 2958 WP_031286087.1 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86602 86602
- inside IScluster/Tn - - 14037..19944 5907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-108)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13960.67 Da        Isoelectric Point: 9.4885

>T271227 WP_013041565.1 NZ_CP117473:17456-17830 [Sphingobium sp. YC-XJ3]
MDTERPVRWVASSKRDFREFPDDVQDVMGYALHLAQQGGQHASTKPLKGFGGAGVVEIIDDHQGDTFRTVYTVKFAEAVY
VLHAFQKKSKQGKATPQADMDLIRTRLKSAEEHHRQHQTPRGTA

Download         Length: 375 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11792.57 Da        Isoelectric Point: 7.1681

>AT271227 WP_006964370.1 NZ_CP117473:17827-18153 [Sphingobium sp. YC-XJ3]
MSAQDEIIEEGSGNVFADLGFADPDTHLLKAQLVTRVAEAMQERKLTQIAAAKVTGSTQPELSRILRGQFRSVSVERLLA
MLTRLGCKVDIVVRPQGRTTESAVIHFA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J7XHG4

Antitoxin

Source ID Structure
AlphaFold DB A0A0J8A803

References