Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2006113..2006952 Replicon chromosome
Accession NZ_CP117471
Organism Sphingobium sp. YC-XJ3

Toxin (Protein)


Gene name tacT Uniprot ID A0A0S3EYY3
Locus tag PO876_RS09710 Protein ID WP_062064438.1
Coordinates 2006437..2006952 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A0S3EYZ1
Locus tag PO876_RS09705 Protein ID WP_062064445.1
Coordinates 2006113..2006421 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO876_RS09675 (PO876_09675) 2001240..2001572 - 333 WP_062064454.1 TrbC/VirB2 family protein -
PO876_RS09680 (PO876_09680) 2001569..2002555 - 987 WP_062064452.1 P-type conjugative transfer ATPase TrbB -
PO876_RS09685 (PO876_09685) 2002808..2003173 + 366 WP_062064450.1 hypothetical protein -
PO876_RS09690 (PO876_09690) 2003243..2003500 - 258 WP_257541981.1 type II toxin-antitoxin system ParD family antitoxin -
PO876_RS09695 (PO876_09695) 2003614..2004036 - 423 WP_062064448.1 CopG family transcriptional regulator -
PO876_RS09700 (PO876_09700) 2004045..2006030 - 1986 WP_062064447.1 conjugal transfer protein TraG -
PO876_RS09705 (PO876_09705) 2006113..2006421 + 309 WP_062064445.1 DUF1778 domain-containing protein Antitoxin
PO876_RS09710 (PO876_09710) 2006437..2006952 + 516 WP_062064438.1 GNAT family N-acetyltransferase Toxin
PO876_RS09715 (PO876_09715) 2006967..2008742 - 1776 WP_062064436.1 DUF3363 domain-containing protein -
PO876_RS09720 (PO876_09720) 2008981..2009562 - 582 WP_062064435.1 hypothetical protein -
PO876_RS09725 (PO876_09725) 2009559..2010266 - 708 WP_062064433.1 lytic transglycosylase domain-containing protein -
PO876_RS09730 (PO876_09730) 2010271..2010615 - 345 WP_062064431.1 DUF736 domain-containing protein -
PO876_RS09735 (PO876_09735) 2010651..2010998 - 348 WP_062064429.1 DUF736 domain-containing protein -
PO876_RS09740 (PO876_09740) 2010979..2011557 - 579 WP_062064427.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-150)

Antitoxin

Vibrio phage ICP1, Orf50

(14-101)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 18179.96 Da        Isoelectric Point: 8.5126

>T271221 WP_062064438.1 NZ_CP117471:2006437-2006952 [Sphingobium sp. YC-XJ3]
VADIRITPPARLTADHDVAGFANGVHASLDDWLRDRALASEGSSARTYVVCNAAEPRRVVGYYTITTAMEQRAALPSAKL
RRGMPDRVPLLLIGRLAVDAGFQGIGLGADLLADALRRCAAAAEIAGARAVIVHAIDEKAAAFYARHGFIPTSLGELVML
LPIEAIRSRPN

Download         Length: 516 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11431.07 Da        Isoelectric Point: 8.8725

>AT271221 WP_062064445.1 NZ_CP117471:2006113-2006421 [Sphingobium sp. YC-XJ3]
MAQTTPAHPNGRASARKDDVIQIRASAGMKAILTRAAALRGQKLSEFMLDSARREAEDAILDQRTFFLDAEQHEQFLAML
DAPPAPSDALQTLMRRKPIWER

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3EYY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3EYZ1

References