Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1414781..1415264 Replicon chromosome
Accession NC_017619
Organism Streptococcus suis SS12

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag SSU12_RS06970 Protein ID WP_012027435.1
Coordinates 1414781..1415041 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSU12_RS06975 Protein ID WP_012775256.1
Coordinates 1415043..1415264 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU12_RS06945 1410166..1411395 - 1230 WP_012775253.1 tetratricopeptide repeat protein -
SSU12_RS06950 1411385..1412551 - 1167 WP_012775254.1 AI-2E family transporter -
SSU12_RS06955 1412687..1413691 + 1005 WP_012028380.1 lactonase family protein -
SSU12_RS06960 1413755..1413940 + 186 WP_002935693.1 hypothetical protein -
SSU12_RS06965 1413973..1414614 - 642 WP_012775255.1 HAD family hydrolase -
SSU12_RS06970 1414781..1415041 - 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU12_RS06975 1415043..1415264 - 222 WP_012775256.1 hypothetical protein Antitoxin
SSU12_RS06980 1415574..1416881 - 1308 WP_002935704.1 phosphopyruvate hydratase -
SSU12_RS06985 1417031..1417483 + 453 WP_012028381.1 DUF1694 domain-containing protein -
SSU12_RS10750 1417490..1417719 - 230 Protein_1322 hypothetical protein -
SSU12_RS06990 1417710..1418837 - 1128 WP_012028382.1 glycerate kinase -
SSU12_RS06995 1418945..1419595 + 651 WP_012027441.1 HAD family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1420032..1421234 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T27122 WP_012027435.1 NC_017619:c1415041-1414781 [Streptococcus suis SS12]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T27122 NC_017619:c1415041-1414781 [Streptococcus suis SS12]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT27122 WP_012775256.1 NC_017619:c1415264-1415043 [Streptococcus suis SS12]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT27122 NC_017619:c1415264-1415043 [Streptococcus suis SS12]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References