271216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2255232..2256210 Replicon chromosome
Accession NZ_CP117421
Organism Bacillus cereus strain 2-6A

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag PRK74_RS11665 Protein ID WP_000624977.1
Coordinates 2255232..2255969 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag PRK74_RS11670 Protein ID WP_000237818.1
Coordinates 2256082..2256210 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRK74_RS11645 (PRK74_11645) 2250875..2251657 + 783 WP_273634872.1 class I SAM-dependent methyltransferase -
PRK74_RS11650 (PRK74_11650) 2251815..2253500 - 1686 WP_119780893.1 alpha-keto acid decarboxylase family protein -
PRK74_RS11655 (PRK74_11655) 2253608..2254090 + 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
PRK74_RS11660 (PRK74_11660) 2254257..2254994 + 738 WP_000594150.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PRK74_RS11665 (PRK74_11665) 2255232..2255969 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PRK74_RS11670 (PRK74_11670) 2256082..2256210 + 129 WP_000237818.1 hypothetical protein Antitoxin
PRK74_RS11675 (PRK74_11675) 2256283..2256459 + 177 WP_000852629.1 stage II sporulation protein SB -
PRK74_RS11680 (PRK74_11680) 2256478..2256867 - 390 WP_000713866.1 YxeA family protein -
PRK74_RS11685 (PRK74_11685) 2257079..2258548 + 1470 WP_128266961.1 beta-Ala-His dipeptidase -
PRK74_RS11690 (PRK74_11690) 2258794..2259603 + 810 WP_119780889.1 papain-like cysteine protease family protein -
PRK74_RS11695 (PRK74_11695) 2259629..2260231 + 603 WP_000517260.1 hypothetical protein -
PRK74_RS11700 (PRK74_11700) 2260472..2260723 - 252 WP_030025648.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T271216 WP_000624977.1 NZ_CP117421:2255232-2255969 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT271216 WP_000237818.1 NZ_CP117421:2256082-2256210 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References