Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240981..241623 Replicon chromosome
Accession NZ_CP117421
Organism Bacillus cereus strain 2-6A

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag PRK74_RS01365 Protein ID WP_000635965.1
Coordinates 241273..241623 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag PRK74_RS01360 Protein ID WP_000004570.1
Coordinates 240981..241268 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRK74_RS01335 (PRK74_01335) 236298..237260 + 963 WP_000961161.1 UV DNA damage repair endonuclease UvsE -
PRK74_RS01340 (PRK74_01340) 237253..237825 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
PRK74_RS01345 (PRK74_01345) 237919..238278 + 360 WP_000583417.1 holo-ACP synthase -
PRK74_RS01350 (PRK74_01350) 238435..239385 + 951 WP_002004297.1 outer membrane lipoprotein carrier protein LolA -
PRK74_RS01355 (PRK74_01355) 239503..240672 + 1170 WP_000390617.1 alanine racemase -
PRK74_RS01360 (PRK74_01360) 240981..241268 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
PRK74_RS01365 (PRK74_01365) 241273..241623 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PRK74_RS01370 (PRK74_01370) 241691..243859 + 2169 WP_000426241.1 Tex family protein -
PRK74_RS01375 (PRK74_01375) 243917..244033 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
PRK74_RS01380 (PRK74_01380) 244228..244686 + 459 WP_000344241.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T271215 WP_000635965.1 NZ_CP117421:241273-241623 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT271215 WP_000004570.1 NZ_CP117421:240981-241268 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References