Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 780989..781539 Replicon plasmid unnamed1
Accession NZ_CP117418
Organism Novosphingobium humi strain KACC 19094

Toxin (Protein)


Gene name parE Uniprot ID G6EGT7
Locus tag PQ457_RS19400 Protein ID WP_007014466.1
Coordinates 781237..781539 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID F6ICG1
Locus tag PQ457_RS19395 Protein ID WP_013831443.1
Coordinates 780989..781234 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ457_RS19375 (PQ457_19375) 776561..777526 + 966 WP_273619450.1 GlxA family transcriptional regulator -
PQ457_RS19380 (PQ457_19380) 777901..779094 - 1194 WP_273619451.1 IS91 family transposase -
PQ457_RS19385 (PQ457_19385) 779099..780007 - 909 WP_273619452.1 tyrosine-type recombinase/integrase -
PQ457_RS19390 (PQ457_19390) 780184..780816 - 633 WP_273619453.1 tyrosine-type recombinase/integrase -
PQ457_RS19395 (PQ457_19395) 780989..781234 + 246 WP_013831443.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PQ457_RS19400 (PQ457_19400) 781237..781539 + 303 WP_007014466.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQ457_RS19405 (PQ457_19405) 781900..782268 - 369 WP_273619455.1 YegP family protein -
PQ457_RS19410 (PQ457_19410) 782588..782773 + 186 WP_273619456.1 hypothetical protein -
PQ457_RS19415 (PQ457_19415) 782770..782991 + 222 WP_273619457.1 hypothetical protein -
PQ457_RS19420 (PQ457_19420) 783053..783742 - 690 WP_273620406.1 spermidine synthase -
PQ457_RS19425 (PQ457_19425) 783742..784236 - 495 WP_273619458.1 YaiI/YqxD family protein -
PQ457_RS19430 (PQ457_19430) 784567..784773 + 207 WP_273619459.1 cold-shock protein -
PQ457_RS19435 (PQ457_19435) 785000..786070 - 1071 WP_273619460.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1319841 1319841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Antitoxin ParD

(1-74)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11270.64 Da        Isoelectric Point: 5.4710

>T271214 WP_007014466.1 NZ_CP117418:781237-781539 [Novosphingobium humi]
VPRFHLTRAAADDLTAIFLEGIEQFGLPQADAYHEGLSAIFAFLADYPHAARLREEISPPVRVHPYKAHLVIYDVGNEGE
VIILRVRHGREDWTSSNYDG

Download         Length: 303 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8969.05 Da        Isoelectric Point: 4.7107

>AT271214 WP_013831443.1 NZ_CP117418:780989-781234 [Novosphingobium humi]
MATMNISLPDPMKQWVEAQADTGRYSNASDYVRDLIRRDQERADKIAAMQRLVDDARAGGLSDETMADIRARAISQAGLQ
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G6EGT7

Antitoxin

Source ID Structure
AlphaFold DB A0A158S7A8

References