Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1367999..1368634 Replicon chromosome
Accession NZ_CP117416
Organism Paenibacillus kyungheensis strain KACC 18744

Toxin (Protein)


Gene name pemK Uniprot ID A0A1E3L8D9
Locus tag PQ456_RS05885 Protein ID WP_069326106.1
Coordinates 1368284..1368634 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PQ456_RS05880 Protein ID WP_069326107.1
Coordinates 1367999..1368280 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ456_RS05860 (PQ456_05860) 1363606..1364862 + 1257 WP_273615298.1 SPFH domain-containing protein -
PQ456_RS05865 (PQ456_05865) 1364864..1365619 + 756 WP_273615299.1 hypothetical protein -
PQ456_RS05870 (PQ456_05870) 1365687..1366340 + 654 WP_273615300.1 hypothetical protein -
PQ456_RS05875 (PQ456_05875) 1366583..1367776 + 1194 WP_273616255.1 alanine racemase -
PQ456_RS05880 (PQ456_05880) 1367999..1368280 + 282 WP_069326107.1 ribbon-helix-helix protein, CopG family Antitoxin
PQ456_RS05885 (PQ456_05885) 1368284..1368634 + 351 WP_069326106.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQ456_RS05890 (PQ456_05890) 1368828..1371053 + 2226 WP_273615301.1 Tex family protein -
PQ456_RS05895 (PQ456_05895) 1371299..1371664 - 366 WP_273615302.1 hydrolase/acyltransferase -
PQ456_RS05900 (PQ456_05900) 1371796..1372281 + 486 WP_273593461.1 SprT family protein -
PQ456_RS05915 (PQ456_05915) 1372682..1373557 - 876 WP_273615303.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-40)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12927.91 Da        Isoelectric Point: 6.4842

>T271213 WP_069326106.1 NZ_CP117416:1368284-1368634 [Paenibacillus kyungheensis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKSHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRRVHDALQISLGLVEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10773.41 Da        Isoelectric Point: 4.9059

>AT271213 WP_069326107.1 NZ_CP117416:1367999-1368280 [Paenibacillus kyungheensis]
MDNMQNAQSIMIRLPDQLLQEVDGIAALEDSDRSELIRKATKIYLTERKKRYIREAMQRGYMEMAKINLRIACEAFHAEE
EADITLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3L8D9

Antitoxin

Source ID Structure

References