Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2466527..2467062 Replicon chromosome
Accession NZ_CP117411
Organism Sphingomonas naphthae strain KACC 18716

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PQ455_RS11875 Protein ID WP_273686294.1
Coordinates 2466742..2467062 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PQ455_RS11870 Protein ID WP_273686293.1
Coordinates 2466527..2466745 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQ455_RS11850 (PQ455_11850) 2464037..2464321 - 285 WP_273686288.1 GNAT family N-acetyltransferase -
PQ455_RS11855 (PQ455_11855) 2464465..2464590 - 126 WP_004210176.1 type B 50S ribosomal protein L36 -
PQ455_RS11860 (PQ455_11860) 2464750..2465343 + 594 WP_273686291.1 DUF4136 domain-containing protein -
PQ455_RS11865 (PQ455_11865) 2465340..2466467 + 1128 WP_273686292.1 M14-type cytosolic carboxypeptidase -
PQ455_RS11870 (PQ455_11870) 2466527..2466745 + 219 WP_273686293.1 antitoxin MazE family protein Antitoxin
PQ455_RS11875 (PQ455_11875) 2466742..2467062 + 321 WP_273686294.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PQ455_RS11880 (PQ455_11880) 2467143..2467697 - 555 WP_273686295.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
PQ455_RS11885 (PQ455_11885) 2467744..2467950 - 207 WP_007404630.1 30S ribosomal protein S21 -
PQ455_RS11890 (PQ455_11890) 2468164..2468712 + 549 WP_273686296.1 (2Fe-2S)-binding protein -
PQ455_RS11895 (PQ455_11895) 2468861..2469637 + 777 WP_273686297.1 RcnB family protein -
PQ455_RS11900 (PQ455_11900) 2469851..2470327 + 477 WP_273686298.1 RcnB family protein -
PQ455_RS11905 (PQ455_11905) 2470428..2471111 - 684 WP_273686299.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Antitoxin MazE-like

(7-69)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11495.46 Da        Isoelectric Point: 10.4418

>T271212 WP_273686294.1 NZ_CP117411:2466742-2467062 [Sphingomonas naphthae]
VRRGDIVTIATPGDFGKPRPALIIQSDQFETGTITVLLVTSTLLDAPLLRPSIQPSPENGLRKPSQVMIDKPMSIRRDRI
GDVFGRLDAETMLAVTRALAVFLGIA

Download         Length: 321 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8347.55 Da        Isoelectric Point: 5.1068

>AT271212 WP_273686293.1 NZ_CP117411:2466527-2466745 [Sphingomonas naphthae]
MAMPISQRVQKRRDAMRAAGLRPIQIWVPDTRREGFTEECRRQARMVAMADAADRDLTDFLDEALLDLERDA

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References