Detailed information of TA system TA027121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-HTH_XRE
• Location: 892328..893571
• Replicon: chromosome
• Accession: NC_017619
• Organism: Streptococcus suis SS12

Toxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A1X9I1V7
• Locus tag: SSU12_RS04420
• Protein ID: WP_014636611.1
• Coordinates: 892328..893095 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: SSU12_RS04425
• Protein ID: WP_014636612.1
• Coordinates: 893095..893571 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSU12_RS04405	888729..889094	-	366	WP_014636608.1	MobC family plasmid mobilization relaxosome protein	-
SSU12_RS04410	889107..889463	-	357	WP_014636609.1	hypothetical protein	-
SSU12_RS04415	889785..892292	-	2508	WP_014636610.1	AAA family ATPase	-
SSU12_RS04420	892328..893095	-	768	WP_014636611.1	zeta toxin family protein	Toxin
SSU12_RS04425	893095..893571	-	477	WP_014636612.1	helix-turn-helix domain-containing protein	Antitoxin
SSU12_RS04430	893641..893931	-	291	WP_014636613.1	hypothetical protein	-
SSU12_RS04435	893981..894370	-	390	WP_014636614.1	hypothetical protein	-
SSU12_RS04440	894367..894594	-	228	WP_014636615.1	hypothetical protein	-
SSU12_RS04445	894648..895724	-	1077	WP_014636616.1	toprim domain-containing protein	-
SSU12_RS04450	895764..896402	-	639	WP_014636617.1	hypothetical protein	-
SSU12_RS04455	896498..896788	-	291	WP_014636618.1	hypothetical protein	-
SSU12_RS04460	896802..897101	-	300	WP_014636619.1	hypothetical protein	-
SSU12_RS04465	897172..898131	-	960	Protein_824	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O)	-	809925..940453	130528

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29142.09 Da
• Isoelectric Point: 5.9860

>T27121 WP_014636611.1 NC_017619:c893095-892328 [Streptococcus suis SS12]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDRPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKRFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDQIQIYQRDRTCIYDSAIDEGSAAEVLQECLFGKWSKVEEEMV
KESELLLNELLEKNK

Nucleotide

• Length: 768 bp

>T27121 NC_017619:c893095-892328 [Streptococcus suis SS12]
ATGAGGTTGGAAGAATTTAGTGAAGCTGAGTTTCAGAAGGCTTTACAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATCCCAGATCGACCAAAAGCTATCTTGCTTGGAGGACAAAGCGGGGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATTATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGAGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGGTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
CAATTGATGAAGGCTCCGCAGCAGAAGTGTTACAAGAGTGTCTCTTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAATGAATTACTTGAGAAAAATAAATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18391.86 Da
• Isoelectric Point: 4.4758

>AT27121 WP_014636612.1 NC_017619:c893571-893095 [Streptococcus suis SS12]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSKVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLRIE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYYGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT27121 NC_017619:c893571-893095 [Streptococcus suis SS12]
ATGATCGGAGACAATATAAAATCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGTAATAGCCTAAGTCGTTATGAGAATGGAACTAGTAAAGTTTCAACAGAACTCATTGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGACAAGATGTTAACACCTGTTGAAGATTACCAATTGACTTTAAGAATAGAA
GTGATCAAAGAACGTGGAGCAGCAATACTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACAAAGATTTACCTTGTCGATACCTTCGATG
AAATTGAGCGTTATTATGGCTACTTAGACGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1X9I1V7