Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 4328170..4329505 | Replicon | chromosome |
| Accession | NZ_CP117404 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain RM085 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A0K4CDG2 |
| Locus tag | PQQ07_RS21095 | Protein ID | WP_001440173.1 |
| Coordinates | 4328558..4329505 (+) | Length | 316 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A0K6A7X2 |
| Locus tag | PQQ07_RS21090 | Protein ID | WP_000208386.1 |
| Coordinates | 4328170..4328565 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQQ07_RS21045 (4323656) | 4323656..4324141 | + | 486 | WP_000213705.1 | antirestriction protein | - |
| PQQ07_RS21050 (4324157) | 4324157..4324633 | + | 477 | WP_001186715.1 | RadC family protein | - |
| PQQ07_RS21055 (4324702) | 4324702..4324923 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| PQQ07_RS21060 (4324942) | 4324942..4325586 | + | 645 | WP_000086770.1 | hypothetical protein | - |
| PQQ07_RS21065 (4325636) | 4325636..4326004 | + | 369 | WP_001285113.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| PQQ07_RS21070 (4326094) | 4326094..4326471 | + | 378 | WP_000854719.1 | TA system toxin CbtA family protein | - |
| PQQ07_RS21075 (4326468) | 4326468..4326956 | + | 489 | WP_000761679.1 | DUF5983 family protein | - |
| PQQ07_RS21080 (4326974) | 4326974..4327171 | + | 198 | WP_000839266.1 | DUF957 domain-containing protein | - |
| PQQ07_RS21085 (4327256) | 4327256..4328101 | + | 846 | WP_001440175.1 | DUF4942 domain-containing protein | - |
| PQQ07_RS21090 (4328170) | 4328170..4328565 | + | 396 | WP_000208386.1 | DUF6088 family protein | Antitoxin |
| PQQ07_RS21095 (4328558) | 4328558..4329505 | + | 948 | WP_001440173.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| PQQ07_RS21100 (4329791) | 4329791..4329868 | - | 78 | Protein_4123 | helix-turn-helix domain-containing protein | - |
| PQQ07_RS21105 (4329959) | 4329959..4330291 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| PQQ07_RS21110 (4330363) | 4330363..4330740 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| PQQ07_RS21115 (4331773) | 4331773..4331847 | + | 75 | Protein_4126 | porin family protein | - |
| PQQ07_RS21120 (4331950) | 4331950..4332702 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| PQQ07_RS21125 (4332950) | 4332950..4333441 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | - |
| PQQ07_RS21130 (4333438) | 4333438..4333731 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | - |
| PQQ07_RS21135 (4334048) | 4334048..4334269 | + | 222 | WP_001576552.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | floR | - | 4300626..4336875 | 36249 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 316 a.a. Molecular weight: 36284.66 Da Isoelectric Point: 6.2532
>T271207 WP_001440173.1 NZ_CP117404:4328558-4329505 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRNRKRKIRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQTFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTELTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQHPQFRNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTN
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRNRKRKIRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQTFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTELTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQHPQFRNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTN
Download Length: 948 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14639.00 Da Isoelectric Point: 11.0607
>AT271207 WP_000208386.1 NZ_CP117404:4328170-4328565 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDRLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDRLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4CDG2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K6A7X2 |