271205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4172969..4173485 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PQQ07_RS20265 Protein ID WP_000220578.1
Coordinates 4172969..4173253 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ07_RS20270 Protein ID WP_000212724.1
Coordinates 4173243..4173485 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS20250 (4168181) 4168181..4169833 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
PQQ07_RS20255 (4170242) 4170242..4172380 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ07_RS20260 (4172501) 4172501..4172965 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ07_RS20265 (4172969) 4172969..4173253 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ07_RS20270 (4173243) 4173243..4173485 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ07_RS20275 (4173563) 4173563..4175476 - 1914 WP_001212137.1 BglG family transcription antiterminator -
PQQ07_RS20280 (4175493) 4175493..4176233 - 741 WP_000779263.1 KDGP aldolase family protein -
PQQ07_RS20285 (4176230) 4176230..4177348 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ07_RS20290 (4177332) 4177332..4178465 - 1134 WP_274896164.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T271205 WP_000220578.1 NZ_CP117404:c4173253-4172969 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT271205 WP_000212724.1 NZ_CP117404:c4173485-4173243 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References