Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4078712..4079288 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQQ07_RS19870 Protein ID WP_001131963.1
Coordinates 4079001..4079288 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PQQ07_RS19865 Protein ID WP_000063142.1
Coordinates 4078712..4079014 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS19850 (4075222) 4075222..4077372 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
PQQ07_RS19855 (4077467) 4077467..4077670 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQQ07_RS19860 (4077681) 4077681..4078637 + 957 WP_000187841.1 GTPase -
PQQ07_RS19865 (4078712) 4078712..4079014 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PQQ07_RS19870 (4079001) 4079001..4079288 - 288 WP_001131963.1 BrnT family toxin Toxin
PQQ07_RS19875 (4079557) 4079557..4080471 - 915 WP_000290512.1 restriction endonuclease -
PQQ07_RS19880 (4080669) 4080669..4084178 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T271204 WP_001131963.1 NZ_CP117404:c4079288-4079001 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT271204 WP_000063142.1 NZ_CP117404:c4079014-4078712 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References