271201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3478059..3478679 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ07_RS17110 Protein ID WP_001280991.1
Coordinates 3478461..3478679 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ07_RS17105 Protein ID WP_000344807.1
Coordinates 3478059..3478433 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS17095 (3473198) 3473198..3474391 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ07_RS17100 (3474414) 3474414..3477563 + 3150 WP_274896137.1 efflux RND transporter permease AcrB -
PQQ07_RS17105 (3478059) 3478059..3478433 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ07_RS17110 (3478461) 3478461..3478679 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ07_RS17115 (3478858) 3478858..3479409 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ07_RS17120 (3479526) 3479526..3479996 + 471 WP_000136181.1 YlaC family protein -
PQQ07_RS17125 (3480052) 3480052..3480192 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ07_RS17130 (3480198) 3480198..3480458 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ07_RS17135 (3480683) 3480683..3482233 + 1551 WP_000213139.1 EAL domain-containing protein -
PQQ07_RS17145 (3482464) 3482464..3482853 + 390 WP_000961285.1 MGMT family protein -
PQQ07_RS17150 (3482886) 3482886..3483455 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T271201 WP_001280991.1 NZ_CP117404:3478461-3478679 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT271201 WP_000344807.1 NZ_CP117404:3478059-3478433 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References