Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 859770..860262 Replicon chromosome
Accession NC_017619
Organism Streptococcus suis SS12

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag SSU12_RS04245 Protein ID WP_011922404.1
Coordinates 859770..860027 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag SSU12_RS04250 Protein ID WP_012775104.1
Coordinates 860011..860262 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU12_RS04225 855404..856474 + 1071 WP_012775101.1 tyrosine recombinase XerS -
SSU12_RS04230 856544..858052 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
SSU12_RS04235 858128..859069 - 942 WP_012775102.1 sensor histidine kinase -
SSU12_RS04240 859066..859731 - 666 WP_012775103.1 response regulator transcription factor -
SSU12_RS04245 859770..860027 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU12_RS04250 860011..860262 - 252 WP_012775104.1 hypothetical protein Antitoxin
SSU12_RS04255 860354..862324 - 1971 WP_014636593.1 FtsX-like permease family protein -
SSU12_RS04260 862325..863077 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
SSU12_RS04265 863213..863947 - 735 WP_011922410.1 ABC transporter permease -
SSU12_RS04270 863949..864695 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) - 809925..940453 130528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T27120 WP_011922404.1 NC_017619:c860027-859770 [Streptococcus suis SS12]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T27120 NC_017619:c860027-859770 [Streptococcus suis SS12]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT27120 WP_012775104.1 NC_017619:c860262-860011 [Streptococcus suis SS12]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT27120 NC_017619:c860262-860011 [Streptococcus suis SS12]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References