Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839787..840447 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ07_RS04050 Protein ID WP_000244756.1
Coordinates 840034..840447 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ07_RS04045 Protein ID WP_000351186.1
Coordinates 839787..840053 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS04025 (835715) 835715..837148 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQQ07_RS04030 (837307) 837307..837618 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQQ07_RS04035 (837782) 837782..838441 + 660 WP_000250289.1 hemolysin III family protein -
PQQ07_RS04040 (838557) 838557..839537 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
PQQ07_RS04045 (839787) 839787..840053 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ07_RS04050 (840034) 840034..840447 + 414 WP_000244756.1 protein YgfX Toxin
PQQ07_RS04055 (840500) 840500..841021 - 522 WP_001055885.1 flavodoxin FldB -
PQQ07_RS04060 (841134) 841134..842030 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ07_RS04065 (842054) 842054..842767 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ07_RS04070 (842773) 842773..844506 + 1734 WP_274896236.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T271193 WP_000244756.1 NZ_CP117404:840034-840447 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT271193 WP_000351186.1 NZ_CP117404:839787-840053 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References