Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206523..207283 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQQ07_RS00970 Protein ID WP_000533909.1
Coordinates 206798..207283 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQQ07_RS00965 Protein ID WP_000965886.1
Coordinates 206523..206810 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS00940 (201818) 201818..202120 + 303 WP_000605590.1 YsaB family lipoprotein -
PQQ07_RS00945 (202259) 202259..203170 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQQ07_RS00950 (203180) 203180..205249 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
PQQ07_RS00955 (205431) 205431..205706 + 276 Protein_189 IS3 family transposase -
PQQ07_RS00960 (205878) 205878..206345 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQQ07_RS00965 (206523) 206523..206810 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQQ07_RS00970 (206798) 206798..207283 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQQ07_RS00975 (207655) 207655..208194 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
PQQ07_RS00980 (208368) 208368..208580 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQQ07_RS00985 (208869) 208869..209159 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQQ07_RS00990 (209598) 209598..210308 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQQ07_RS00995 (210358) 210358..211332 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQQ07_RS01000 (211551) 211551..212213 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T271190 WP_000533909.1 NZ_CP117404:206798-207283 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT271190 WP_000965886.1 NZ_CP117404:206523-206810 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References