Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4127652..4128433 Replicon chromosome
Accession NZ_CP117402
Organism Salmonella enterica subsp. enterica serovar Give strain RM007

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3V8KWJ7
Locus tag PQQ13_RS20175 Protein ID WP_001609688.1
Coordinates 4127652..4128143 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag PQQ13_RS20180 Protein ID WP_001110453.1
Coordinates 4128140..4128433 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ13_RS20150 (4122788) 4122788..4125226 - 2439 WP_001014136.1 F4 (K88) fimbrial usher FaeD -
PQQ13_RS20155 (4125236) 4125236..4125775 - 540 WP_000721295.1 type 1 fimbrial protein -
PQQ13_RS20160 (4125810) 4125810..4126100 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQQ13_RS20165 (4126687) 4126687..4126914 + 228 WP_001112992.1 hypothetical protein -
PQQ13_RS20170 (4127189) 4127189..4127437 - 249 Protein_3939 IS481 family transposase -
PQQ13_RS20175 (4127652) 4127652..4128143 - 492 WP_001609688.1 GNAT family N-acetyltransferase Toxin
PQQ13_RS20180 (4128140) 4128140..4128433 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
PQQ13_RS20185 (4128751) 4128751..4128973 + 223 Protein_3942 hypothetical protein -
PQQ13_RS20190 (4129237) 4129237..4130112 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQQ13_RS20195 (4130109) 4130109..4130396 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ13_RS20200 (4130389) 4130389..4130571 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
PQQ13_RS20205 (4130591) 4130591..4130690 + 100 Protein_3946 hypothetical protein -
PQQ13_RS20210 (4130800) 4130800..4130934 + 135 Protein_3947 hypothetical protein -
PQQ13_RS20215 (4131229) 4131229..4132134 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4116031..4130571 14540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17664.46 Da        Isoelectric Point: 7.2655

>T271187 WP_001609688.1 NZ_CP117402:c4128143-4127652 [Salmonella enterica subsp. enterica serovar Give]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVEETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT271187 WP_001110453.1 NZ_CP117402:c4128433-4128140 [Salmonella enterica subsp. enterica serovar Give]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8KWJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References