Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3989755..3990271 Replicon chromosome
Accession NZ_CP117402
Organism Salmonella enterica subsp. enterica serovar Give strain RM007

Toxin (Protein)


Gene name relE Uniprot ID A0A5J2LRU5
Locus tag PQQ13_RS19455 Protein ID WP_001609934.1
Coordinates 3989755..3990039 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ13_RS19460 Protein ID WP_000212724.1
Coordinates 3990029..3990271 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ13_RS19440 (3984871) 3984871..3986523 + 1653 WP_023212814.1 alpha,alpha-phosphotrehalase -
PQQ13_RS19445 (3986932) 3986932..3989070 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ13_RS19450 (3989287) 3989287..3989751 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ13_RS19455 (3989755) 3989755..3990039 - 285 WP_001609934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ13_RS19460 (3990029) 3990029..3990271 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ13_RS19465 (3990349) 3990349..3992262 - 1914 WP_001609931.1 BglG family transcription antiterminator -
PQQ13_RS19470 (3992279) 3992279..3993019 - 741 WP_023229489.1 KDGP aldolase family protein -
PQQ13_RS19475 (3993016) 3993016..3994134 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ13_RS19480 (3994118) 3994118..3995251 - 1134 WP_001609909.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 10859.66 Da        Isoelectric Point: 9.3941

>T271186 WP_001609934.1 NZ_CP117402:c3990039-3989755 [Salmonella enterica subsp. enterica serovar Give]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSACLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT271186 WP_000212724.1 NZ_CP117402:c3990271-3990029 [Salmonella enterica subsp. enterica serovar Give]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5J2LRU5


Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References