Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3949137..3949687 Replicon chromosome
Accession NZ_CP117402
Organism Salmonella enterica subsp. enterica serovar Give strain RM007

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag PQQ13_RS19255 Protein ID WP_001199743.1
Coordinates 3949137..3949445 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag PQQ13_RS19260 Protein ID WP_000016243.1
Coordinates 3949448..3949687 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ13_RS19245 (3944537) 3944537..3948052 - 3516 WP_000342548.1 AAA domain-containing protein -
PQQ13_RS19250 (3948414) 3948414..3948715 - 302 Protein_3760 Arm DNA-binding domain-containing protein -
PQQ13_RS19255 (3949137) 3949137..3949445 - 309 WP_001199743.1 CcdB family protein Toxin
PQQ13_RS19260 (3949448) 3949448..3949687 - 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PQQ13_RS19265 (3949796) 3949796..3950020 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
PQQ13_RS19275 (3950805) 3950805..3951824 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
PQQ13_RS19280 (3951852) 3951852..3952382 - 531 WP_023231125.1 gluconokinase -
PQQ13_RS19285 (3952599) 3952599..3953630 + 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
PQQ13_RS19290 (3953655) 3953655..3954419 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T271185 WP_001199743.1 NZ_CP117402:c3949445-3949137 [Salmonella enterica subsp. enterica serovar Give]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT271185 WP_000016243.1 NZ_CP117402:c3949687-3949448 [Salmonella enterica subsp. enterica serovar Give]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References